個人簡介
戴阿光，理學博士🤹🏽♂️，中國科沐鸣2上海免疫與感染研究所研究員。2014年於美國佛羅裏達州立大學獲得分子生物物理學博士學位，2014-2017年先後在美國FSU👩🏿🍳、Brandeis Univ.和Southwestern Medical Center進行博士後研究，並於2017-2020年任美國Univ. Of Texas at Austin冷凍電鏡平臺主任。目前發表論文7篇論文🔄，授權中國發明專利1項🚁，創建的電鏡平臺在世界上第一個獲得新冠刺突蛋白冷凍電鏡結構並應用到輝瑞和摩德納等數個疫苗中，主持研究所十三五科教基礎設施P2冷凍電鏡平臺建設。
研究方向
原位冷凍斷層掃描成像技術在感染與免疫上的應用
冷凍電鏡高分辨高通量技術研究
主持與承擔主要項目情況
Codelivery of SARS-CoV-2 Prefusion-Spike Protein with CBLB502 by a Dual-Chambered Ferritin Nanocarrier Potentiates Systemic and Mucosal Immunity. ACS Appl Bio Mater. 2022 Jul 18;5(7):3329-3337
2.Wang W;Wang Z; Yang X; Gao Y; Zhang X; Cao L;Dai A; Sun J; Sun L; Jiang L; Chen Z; Wang L.The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum. Cell Discov. 2021 Oct 19;7(1):94. doi: 10.1038/s41421-021-00324-8.
3.Long Gui; Kangkang Song; Douglas Trischler; Raqual Bower; Si Yan; Aguang Dai; Katherine Augspurger; Jason Sakizadeh; Magdalena Grzemska; Thomas Ni; Mary E. Porter* ; Daniela Nicastro* ; Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex, Proc Natl Acad Sci USA, 2019, 116(46): 23152-23162.
4.Aguang Dai; Feng Ye; Danne W. Taylor; Guiqing Hu; Mark H. Ginsberg* ; Kenneth A. Taylor* ; The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand, J Biol Chem, 2015, 290(45): 27168-27175.
5. Shuyu Liu# ; Jian He# ; Chiaho Shih; Kupeng Li; Aguang Dai; Z. Hong Zhou* ; Jingqiang Zhang* ; Structural comparisons of hepatitis B core antigen particles with different C-terminal lengths, Virus Res., 2010, 149(2): 241-244. (4) Liu Shuyu# ; He Jian# ; Li Kunpeng; Dai Aguang; 6. Cai Changjie; Zhang Jingqiang* ; Three-dimensional structure of the hepatitis B core antigen particle truncated at residue 154, Sci China Life Sci, 2010, 54: 171-174. (期刊論文)
7. Zhihong Li; Jian He; Xiaojun Huang; Aguang Dai; Lingpeng Cheng; Dingyong Shao; Jingqiang Zhang* ; The truncated virus-like particles of C6/36 cell densovirus: implications for the assembly mechanism of brevidensovirus, Virus Res., 2008, 132(1-2): 248-252.
聯系方式
Email：agdai@ips.ac.cn
辦公地址👨🏻🦳：上海徐匯嶽陽路320號生命科學實驗樓B407